Acute Kidney Injury (AKI)
Acute kidney injury (AKI) is defined as an abrupt or rapid decline in renal filtration function due to renal tissue damage. AKI is characterized by a decrease in glomerular filtration rate and urine output accompanied by increased serum creatinine and urea levels. The underlying renal tissue damage can be caused endogenously (e.g. by decreased renal blood flow or urinary tract obstruction impeding urine flow) or exogenously (e.g. by certain drugs including cytostatic drugs like cisplatin).
ABCB5-positive mesenchymal stem cells (ABCB5+ MSCs) have proven effective in restoring renal function in experimental models of AKI. Thus, stem cell therapy using ABCB5+ MSCs could represent a promising treatment approach for AKI.
The precise effect in vivo and in vitro is currently studied in further trials.