Peripheral Arterial Occlusive Disease – Allogeneic
We are recruiting patients with peripheral arterial occlusive disease (PAOD) for a multicentric, randomized, placebo-controlled, double-blind phase I/IIa clinical trial.
The aim of the trial is to examine the efficacy and safety of allogeneic ABCB5-positive mesenchymal stem cells (ABCB5+ MSCs) in patients with PAOD. Primary endpoints are the percentage of wound size reduction and the occurrence of adverse events.
For this trial 76 patients will be recruited at 9 sites in Germany and Austria.
For the manufacturing process of the allogeneic ABCB5+ MSCs we are using a patent hold by the Brigham and Women’s Hospital, Boston/USA, and the Children’s Hospital, Boston/USA, in cooperation with our scientific partner Prof. Dr. Markus Frank.
Background information about the use of ABCB5+ MSCs in PAOD can be found HERE.
Study CentersIf you are interested, please contact the corresponding center.
- Kiel: University Hospital Schleswig-Holstein, Campus Kiel, Department of internal medicine III with a focus on cardiology, angiology and internal intensive care medicine
- Dresden: Medical Clinic and Polyclinic III, University Hospital "Carl Gustav Carus", Technical University of Dresden
- Hamburg: Asklepios Hospital Harburg, Vascular Center Hamburg, Department of Angiology
- Hamburg: University Heart Center (UHZ)
- Heidelberg: St. Josef Hospital Heidelberg, Clinical Study Department
- Karlsbad-Langensteinbach: SRH Klinikum Karlsbad-Langensteinbach, Internal Medicine / Interdisciplinary Vascular Center
- Trier: Medical care center of the brothers of mercy Trier, Internal Medicine
University Hospital Schleswig-Holstein, Campus Kiel
Department of internal medicine III with a focus on
cardiology, angiology and internal intensive care medicine
Asklepios Hospital Harburg
Vascular Center Hamburg
Department of Angiology
University Heart Center (UHZ)
Medical Clinic and Polyclinic III
University Hospital "Carl Gustav Carus"
Technical University of Dresden
Medical care center of the
brothers of mercy Trier
St. Josef Hospital Heidelberg
Clinical Study Department
SRH Klinikum Karlsbad-Langensteinbach
Internal Medicine / Interdisciplinary Vascular Center